The Korotkova Lab
We study structural organization and function
of cell envelope in Gram-positive bacteria
ABOUT US
The plasma membrane of Gram-positive bacteria is surrounded by thick cell wall that consists of a complex network of peptidoglycan with covalently attached polysaccharides.
While peptidoglycan is very well studied, the structures and biosynthesis of the polysaccharides remain largely unexplored in many Gram-positive bacteria. These polysaccharides play critical functions in cell division, antibiotic resistance, metal ion homeostasis, and protection of bacteria from host defense peptides and antimicrobial enzymes. These structures and their biosynthetic pathways are attractive targets for therapeutic intervention, such as antibiotic development and vaccine design.
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